Mechanism of Action
Retatrutide is a triple-agonist peptide that simultaneously activates three key metabolic receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). This unique mechanism provides comprehensive metabolic benefits:
- GLP-1 Receptor Activation:Enhances glucose-dependent insulin secretion, improving postprandial glucose control.Slows gastric emptying, promoting satiety and reducing food intake.Suppresses glucagon secretion, further aiding in glucose regulation.
- GIP Receptor Activation:Stimulates insulin secretion in a glucose-dependent manner, enhancing insulin sensitivity.Contributes to fat metabolism and preservation of β-cell function.
- Glucagon Receptor Activation:Increases energy expenditure through hepatic glucose output and lipid mobilization.Promotes fatty acid oxidation and thermogenesis, supporting weight reduction.
- The combination of these actions results in a synergistic effect that enhances weight loss, improves glycemic control, and optimizes overall metabolic health.
Applications
- Type 2 Diabetes Management: Retatrutide helps regulate blood glucose levels and improve glycemic control.
- Weight Management: It has demonstrated significant weight loss benefits, making it suitable for obesity management.
- Non-Alcoholic Fatty Liver Disease (NAFLD): Retatrutide has shown potential in reducing liver fat content.
- Metabolic Syndrome: It addresses multiple aspects of metabolic dysfunction, including lipid metabolism and energy expenditure.
Dosage Instructions
- Initial Dose: The starting dose is typically 2.5 mg once weekly.
- Titration: The dose can be increased to 5 mg, 10 mg, or higher, depending on individual response and tolerability.
- Injection Instructions: Administered subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites to avoid lipodystrophy.
- Missed Dose: If a dose is missed, administer as soon as possible within 3 days. If more than 3 days have passed, skip the missed dose and resume the regular schedule.
Storage
- Unopened Pens: Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze.
- Opened Pens: Once opened, pens can be stored at room temperature (not exceeding 30°C/86°F) for up to 8 weeks.
- Protection from Light and Heat: Keep the medication away from direct sunlight and high temperatures.
