Prefilled syringe filling sealing line
Aseptic pre-filling and sealing syringe lines are mainly used for the unpacking, tearing, filling and pluging of disposable syringes in honeycomb trays in pharmaceutical plants. It's mainly for the production and packaging of various aseptic products such as vaccines, monoclonal antibodies, small molecule heparin, insulin and hyaluronic acid.
Performance Features
The design, materials, manufacturing, assembly and commissioning of the entire plastic pfs line are in accordance with the new GMP regulations.
This machine adopts servo control system to automatically complete the processes of honeycomb tray unpacking, tearing film, conveying, filling, plug feeding, plug filling and tray output. It's with electromechanical integration control, stable operation and high degree of automation.
Applications: 1ml - 20ml (according to user specifications);
Filling range of plastic pfs machine: 0.1ml-20ml
Capacity: 2000-30000 bph
Filling head: 2-10 pcs, choose according to capacity;
Various types of filling pump options: metal pump, peristaltic pump, ceramic pump;
Filling accuracy: ≤ ± 1% (depending on the characteristics of the medicine).
Pass rate ≥99.9%
Automatic removal and return of the syringe from the honeycomb tray by means of a servo system combined with a cylinder;
Fully automatic production control with intelligent testing devices at the core stations;
No friction between the contact surface of the pluger and the drug solution and the bottom rail during transport. The stopper is always protected by laminar flow, avoiding the risk of particles and contamination;
The main drive components of the machine are servo-driven and are located in the lower part of the machine frame, which allows precise positioning and avoids pollution of the environment;
Can be equipped with a servo motor controlled filling pump for filling, which is highly accurate and easy to adjust;
Configurable filling system CIP/SIP system;
A nitrogen filling unit can be configured to isolate the medicinal solution from oxygen;
Can be equipped with a vacuum filling system for filling the high viscous products;
Configurable with Open-RABS isolation protection system and Class 100 air purification laminar flow system;
The high-performance no bottle no filling, no bottle no capping and linked bottle squeeze stop function can be configured;
Can be equipped with multiple robots for collaborative control technology to fully automate the process of tearing film, de-lining, filling, pluging and weighing of pre-filled syringes
The automatic calibration of the filling volume can be configured to calibrate the filling volume fully automated;
Can be equipped with fully closed aseptic isolation (Isolator) systems and bag-in-bag-out (BIBO) systems if needed;
Fully automatic control and monitoring of the production process using control technologies such as high-precision colour touch screen operation and monitoring, PLC automatic control, automatic protection and mainframe variable frequency speed regulation;
Can customized relevant products according to the actual needs of the customer
Ampoule liquid washing filling sealing line
Main Application
The ampoule liquid filling sealing production line is composed of ultrasonic bottle washing machine, dryer sterilizer and ampoule filling and sealing machine. It can complete spraying water, ultrasonic cleaning, air & water flushing of inner and outer wall of ampoule bottle, preheating, drying and sterilization, heat source removing, cooling, (nitrogen pre-filling), filling, (nitrogen post-filling), ampoule sealing and other complex functions, realizing automatic production of the whole process. Each machine can be used separately or in linkage line. The whole line is mainly used for ampoule injections filling in pharmaceutical factories and the general type can also be used for antibiotic vial injection filling or powder filling.
Performance Features
1.The whole ampoule filling line meets new GMP requirements, and the cleaning effect meets the new Pharmacopoeia standards and requirements.
2.The whole aseptic ampoule liquid filling line can adopt straight-line layout or wall-to-wall L-shaped layout to reduce risk of cross-contamination and ensure aseptic level.
3.Applicable specification: 1ml-20ml ampoule (as per user's requirement)
4.Production Capacity for sterile ampoule filling machine : 12000-36000BPH
5.Number of filling head: 2-20, to be selected according to output
6.Filling Accuracy: ≤ ±1% (according to drug characteristics)
7.Choice of various filling pumps: glass pump, metal pump, peristaltic pump, ceramic pump;
8.Compact and simple structure, occupies less area;
9. Stable product performance, easy and reliable operation, beautiful appearance;
10. High degree of automation, fewer operators required;
11.Various sealing gas supply methods such as natural gas or hydrogen and oxygen gas;
12.Optional real-time display and printing system of sterilization temperature;
13.The maximum sterilization temperature of hot air circulation tunnel oven is 350ºC;
14. The heat in the hot air circulation tunnel oven is evenly distributed, and the heat resources removal effect is
good.
15.Optional open-RABS isolation protection system and class 100 laminar flow hood protection;
16.Optional high-performance no-bottle-no-filling function and squeeze stop function;
17.The filling machine can be equipped with online monitoring system to monitor key factors that affect product
quality (such as dust particles, planktonic bacteria, wind speed, wind pressure, etc.).
18.Full-line linkage control and operation function for Pharmaceutical Automatic Ampoule Washing Sterilizing Filling Sealing Production Machine ;
19.To realize fully automatic control and monitor of production process, high precision colored touch screen
operation monitoring, PLC automatic control & automatic protection, main machine frequency conversion speed
regulation and other control technology are used.
20.Applicable for wide range of bottle specifications, and easy to replace mould.
21.The products can be customized according to customer's actual demand.
vial powder washing filling capping line
Main ApplicationThe vial powder filling production line is composed of the ultrasonic bottle washing machine, dryer sterilizer, filling and stoppering machine, and capping machine. It can complete spraying water, ultrasonic cleaning, flushing of the inner and outer wall of the bottle, preheating, drying and sterilization, heat source removing, cooling, bottle unscrambling, filling, plug unscrambling, stopper pressing, cap unscrambling, capping, and other complex functions, realizing automatic production of the whole process. Each machine can be used separately or in a linkage line, which is mainly used in the production of vial sterile powder filling.Performance Features1. The whole auger powder filling line meets new GMP requirements, and the cleaning effect meets the newPharmacopoeia standards and requirements.2. The whole vial powder filling machine can adopt a straight-line layout to reduce the risk of drug cross-contamination and ensure aseptically level.3. Applicable specification: 5ml-50ml vial (as per user's requirement)4. Production Capacity: 6000-30000BPH for powder filling machine5. Number of filling heads: 1-4, to be selected according to output6. Filling Accuracy: ≤ ±1% (according to drug characteristics)7. Capping qualified rate: ≥99.9% 8. Compact and simple structure occupies less area;9. Stable product performance, easy and reliable operation, beautiful appearance;10. High degree of automation, fewer operators required;11. Optional real-time display and printing system of sterilization temperature;12. The heat in the hot air circulation tunnel oven is evenly distributed, and the heat resources removal effect is good.13. Optional online sterilization function for the cooling section of hot air circulation tunnel oven.14. Various type of filling heads can be designed based on different filling volume, filling accuracy is high;15. The feeding system adopts various aseptic material transfers, which meet the GMP requirements.17. Multi-head screw intermittent filling, directly filling sterile raw materials into bottles, no secondary pollution.18. Optional open-RABS isolation protection system and class 100 laminar flow hood protection;19. Optional high-performance no-bottle-no-filling, no bottle no stoppering, no bottle no capping and squeezestop functions;20. The capping machine can be equipped with a dust exhaust device, which can absorb aluminumscraps produced during capping and thus reduce the risk of environmental pollution.21. The powder filling line can be equipped with an online monitoring system to monitor key factors that affect productquality (such as dust particles, planktonic bacteria, wind speed, wind pressure, etc.).22. Full-line linkage control function;23. To realize fully automatic control and monitoring of the production process, high precision colored touch screen operation monitoring, PLC automatic control & automatic protection, main machine frequency conversion speed regulation, and other control technologies are used.24. Applicable for a wide range of bottle specifications, and easy to replace mold.25. The products can be customized according to the actual demand of customers.
